It is shown that Lewis’ ontological doctrine of Humean supervenience incorporates at its foundation the so-called separability principle of classical physics. In view of the systematic violation of the latter within quantum mechanics, the claim that contemporary physical science may posit non-supervenient relations beyond the spatiotemporal ones is reinforced on a foundational basis concerning constraints on the state-representation of physical systems. Depending on the mode of assignment of states to physical systems — unit state vectors versus statistical density operators — we distinguish between strongly and weakly non-Humean, non-supervenient relations. It is demonstrated that in either case the relations of quantum entanglement consti...