Sustained Delivery Of Insulin-Like Growth Factor-1/Hepatocyte Growth Factor Promotes Endogenous Cardiac Repair And Regeneration In The Chronic Ischemic Heart
- Koudstaal, Stefan
- Bastings, Maartje
- Ellison, Georgina
- Feyen, Dries
- Waring, Cheryl
- Torella, Daniele
- Meijer, Bert
- Sluijter, Joost
- Nadal-Ginard, Bernardo
- Doevendans, Pieter
- Dankers, Patricia
- Chamuleau, Steven
DOIAbstract
The aim of this study was to test the sustained release of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) using an injectable supramolecular hydrogel based on ureido-pyrimidinone (UPy) moieties in order to recruit and activate endogenous porcine cardiac stem/progenitor cells (epCSCs) towards the infarct borderzone leading to increased myocardial repair in a porcine model of chronic myocardial infarction (MI)
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