The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques
- Montecucco, Fabrizio
- Di Marzo, Vincenzo
- da Silva, Rafaela F.
- Vuilleumier, Nicolas
- Capettini, Luciano
- Lenglet, Sebastien
- Pagano, Sabrina
- Piscitelli, Fabiana
- Quintao, Silvia
- Bertolotto, Maria
- Pelli, Graziano
- Galan, Katia
- Pilet, Lucie
- Kuzmanovic, Kristina
- Burger, Fabienne
- Pane, Bianca
- Spinella, Giovanni
- Braunersreuther, Vincent
- Gayet-Ageron, Angele
- Pende, Aldo
- Viviani, Giorgio Luciano
- Palombo, Domenico
- Dallegri, Franco
- Roux-Lombard, Pascale
- Santos, Robson A. S.
- Stergiopulos, Nikos
- Steffens, Sabine
- Mach, Francois
DOIAbstract
The activation of cannabinoid receptor type 2 (CB2)-mediated pathways might represent a promising anti-atherosclerotic treatment. Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB2 pharmacological activation on markers of plaque vulnerability in vivo and in vitro
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