A modular synthesis of the marine natural product largazole and related synthetic analogs is described. Largazole was prepd. in 10% overall yield through a synthetic route with a longest linear sequence of nine steps. Activity tests showed the necessity of the thiobutenyl moiety for antiproliferative activity
We report the design, synthesis, and biological evaluation of a new series of largazole analogues in...
<p>Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, and</p><p>have b...
Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the poten...
The total synthesis of largazole and four analogues is reported. All analogues were nanomolar HDAC i...
Natural products with interesting biological properties and structural diversity have often served a...
The efficient total synthesis of the recently described natural substance largazole (1) and its acti...
A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating ma...
The dissertation describes the total synthesis of (+)-largazole, the development of multicomponent r...
The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is describe...
The marine natural product Largazole is the most potent Class I HDAC inhibitor identified to date. S...
The stereocontrolled total synthesis of largazole was accomplished, unambiguously confirming its str...
<p>Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human mor...
<p>The dissertation focuses on three main projects which complement the studies towards the total sy...
2018 Summer.Includes bibliographical references.Natural product histone deacetylase inhibitor, Larga...
Since the time of its identification, the natural compound largazole rapidly caught the attention of...
We report the design, synthesis, and biological evaluation of a new series of largazole analogues in...
<p>Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, and</p><p>have b...
Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the poten...
The total synthesis of largazole and four analogues is reported. All analogues were nanomolar HDAC i...
Natural products with interesting biological properties and structural diversity have often served a...
The efficient total synthesis of the recently described natural substance largazole (1) and its acti...
A number of analogues of the marine-derived histone deacetylase inhibitor largazole incorporating ma...
The dissertation describes the total synthesis of (+)-largazole, the development of multicomponent r...
The synthesis of an isosteric analog of the natural product and HDAC inhibitor largazole is describe...
The marine natural product Largazole is the most potent Class I HDAC inhibitor identified to date. S...
The stereocontrolled total synthesis of largazole was accomplished, unambiguously confirming its str...
<p>Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human mor...
<p>The dissertation focuses on three main projects which complement the studies towards the total sy...
2018 Summer.Includes bibliographical references.Natural product histone deacetylase inhibitor, Larga...
Since the time of its identification, the natural compound largazole rapidly caught the attention of...
We report the design, synthesis, and biological evaluation of a new series of largazole analogues in...
<p>Histone deacetylases (HDACs) have been shown to play key roles in tumorigenesis, and</p><p>have b...
Histone deacetylase inhibitors are an emerging class of antiproliferative agents that have the poten...
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