The leukaemia associated antigen, SSX2IP, is expressed during mitosis on the surface of myeloid leukaemia cells

  • Denniss, Frances A.K.
  • Breslin, Angela
  • Ingram, Wendy
  • Hardwick, Nicola R.
  • Mufti, Ghulam J.
  • Guinn, Barbar-Ann
Publication date
September 2007
Publisher
Wiley

Abstract

We have shown for the first time the surface expression pattern of SSX2IP during mitosis which provides an interesting insight into SSX2IP protein expression in human malignancy. Therapeutically the removal of SSX2IP positive cells from AML patient stem cell harvests has the potential to reduce the tumour burden for patients whose graft fails or for patients who lack a suitable stem cell donor, although these possibilities require further investigatio

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