Polyhydroxyazepanes mimicking monosaccharides: Synthesis of an alpha-D-galacto-like iminoheptitol

Li, H. Q.
Breriot, Y.
Mallet, J. M.
Zhang, Y. M.
Rodriguez-Garcia, E.
Vogel, P.
Mari, S.
Jimenez-Barbero, J.
Sinay, P.

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Publication date

November 2005

DOI

10.3987/COM-04-S(P)45

Publisher

Japan Institute of Heterocyclic Chemistry

Abstract

The synthesis of three new examples of seven-membered ring iminoalditols, displaying an extra hydroxymethyl group on the ring compared to the previously reported polyhydroxylated azepanes, has been achieved from D-lyxonolactone. None of them, including the alpha-D-galacto-like azepane (7), showed significant glycosidase inhibition on green coffee bean alpha-galactosidase and other commercially available hydrolases

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Polyhydroxyazepanes mimicking monosaccharides: Synthesis of an alpha-D-galacto-like iminoheptitol

Abstract

Extracted data

Polyhydroxyazepanes mimicking monosaccharides: Synthesis of an alpha-D-galacto-like iminoheptitol

Abstract

Extracted data

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