Ursolic acid (UA) has been recently proposed as a potential candidate for the treatment of muscle wasting conditions because of its protein sparring/anabolic effects. Despite this finding, it is unknown whether this response is the consequence of a direct effect on the muscle fibre or if it is mediated by neural or other systemic factors. In the present study, we sought to determine if UA has direct effects in skeletal muscle cells, whether it can increase myoblast proliferation and whether UA can become myotoxic at higher doses. Our results demonstrate that UA directly promoted protein accretion in cultured myotubes but did not modulate myoblast proliferation. At higher doses, UA compromised cell viability in both myoblasts and myotubes. W...
International audienceIn skeletal muscle, chronic oxygen depletion induces a disturbance leading to ...
Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availab...
Branched-chain amino acids (BCAAs) are essential amino acids that are crucial for skeletal muscle an...
Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose int...
<div><p>Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glu...
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation...
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation...
SummarySkeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic the...
Resistance exercise (RE) stimulates skeletal muscle protein synthesis (MPS) during post-exercise rec...
Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associate...
Ursolic acid is a pentacyclic triterpene found in a wide variety of commonly\ud consumed fruits and ...
Background: Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This s...
A Distrofia Muscular de Duchenne (DMD) é uma doença hereditária ligada ao cromossomo ‘X’...
peer reviewedBACKGROUND: The control of muscle size is an essential feature of health. Indeed, skele...
We recently suggested that, in muscular dystrophies, the excessive accumulation of adenosine as a re...
International audienceIn skeletal muscle, chronic oxygen depletion induces a disturbance leading to ...
Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availab...
Branched-chain amino acids (BCAAs) are essential amino acids that are crucial for skeletal muscle an...
Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose int...
<div><p>Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glu...
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation...
Spinal Cord Injury (SCI) results in severe sub-lesional muscle atrophy and fiber type transformation...
SummarySkeletal muscle atrophy is a common and debilitating condition that lacks a pharmacologic the...
Resistance exercise (RE) stimulates skeletal muscle protein synthesis (MPS) during post-exercise rec...
Elevated serum uric acid is a risk factor for mortality in diseases and critical illnesses associate...
Ursolic acid is a pentacyclic triterpene found in a wide variety of commonly\ud consumed fruits and ...
Background: Ursolic acid (UA) is thought to have an anabolic effect on muscle mass in humans. This s...
A Distrofia Muscular de Duchenne (DMD) é uma doença hereditária ligada ao cromossomo ‘X’...
peer reviewedBACKGROUND: The control of muscle size is an essential feature of health. Indeed, skele...
We recently suggested that, in muscular dystrophies, the excessive accumulation of adenosine as a re...
International audienceIn skeletal muscle, chronic oxygen depletion induces a disturbance leading to ...
Dietary L-citrulline is thought to modulate muscle protein turnover by increasing L-arginine availab...
Branched-chain amino acids (BCAAs) are essential amino acids that are crucial for skeletal muscle an...