Room Temperature, Metal-Free Synthesis of Diaryl Ethers with Use of Diaryliodonium Salts

A fast, high-yielding synthesis of diaryl ethers with use of mild and metal-free conditions has been developed. The scope includes bulky ortho-substituted diaryl ethers, which are difficult to obtain by metal-catalyzed protocols. Halo-substituents, racemization-prone amino acid derivatives, and heteroaromatics are also tolerated. The methodology is expected to be of high utility in the synthesis of complex molecules and in the pharmaceutical industry.Swedish Research CouncilSwedish Research CouncilSwedish Foundation for International Cooperation in Research and Higher Education (STINT)Swedish Foundation for International Cooperation in Research and Higher Education (STINT)CNPqConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq