Abnormal Corpus Callosum Integrity in Bipolar Disorder: A Diffusion Tensor Imaging Study

Objective: Abnormalities in the anterior interhemispheric connections provided by the corpus callosum (CC) have long been implicated in bipolar disorder (BID). In this study, we used complementary diffusion tensor imaging methods to study the structural integrity of the CC and localization of potential abnormalities in BD. Methods: Subjects included 33 participants with BID and 40 healthy comparison participants. Fractional anisotropy (FA) measures were compared between groups with region of interest (ROD methods to investigate the anterior, middle, and posterior CC and voxel-based methods to further localize abnormalities. Results: In ROI-based analyses, FA was significantly decreased in the anterior and middle CC in the BID group (p <.05). Voxel-based analyses similarly localized group differences to the genu, rostral body, and anterior midbody of CC (p <.05, corrected). Conclusion: The findings demonstrate abnormalities in the structural integrity of the anterior CC in BID that might contribute to altered interhemispheric connectivity in this disorder.National Institute of Mental Health (NIH)National Institute of Mental Health (NIH)[R01MH69747]National Institute of Mental Health (NIH)National Institute of Mental Health (NIH)[R01MH070902]National Institute of Mental Health (NIH)National Institute of Mental Health (NIH)[T32MH14276]National Institute of Mental Health (NIH)National Institute of Mental Health (NIH)[R01 EB006494]National Institute of Mental Health (NIH)[K23MH077914]National Institute of Mental Health (NIH)The Department of Veterans Affairs Career DevelopmentThe Department of Veterans Affairs Career DevelopmentMerit ReviewMerit ReviewResearch Enhancement Award Program (REAP)Research Enhancement Award Program (REAP)Attias Family FoundationAttias Family FoundationMarcia Simon KaplanMarcia Simon KaplanKlingenstein FoundationKlingenstein FoundationAlational InstitutesAlational InstitutesHealth (NIH)/National Center for Research Resources/Clinical and Translational Science AwardsHealth (NIH)/National Center for Research Resources/Clinical and Translational Science Awards[UL1RR024139-01]NIH/National Institute of Biomedical Imaging and Bioengineering[R01 EB006494]NIH/National Institute of Biomedical Imaging and Bioengineerin