Conventional Versus Biventricular Pacing in Heart Failure and Bradyarrhythmia: The COMBAT Study
- MARTINELLI FILHO, Martino
- SIQUEIRA, Sergio Freitas De
- COSTA, Roberto
- GRECO, Oswaldo T.
- MOREIRA, Luiz Felipe
- D`AVILA, Andre
- HEIST, E. Kevin
DOIAbstract
Background: Worsening in clinical and cardiac status has been noted after chronic right ventricular pacing, but it is uncertain whether atriobiventricular (BiVP) is preferable to atrio-right ventricular pacing (RVP). Conventional versus Multisite Pacing for BradyArrhythmia Therapy study (COMBAT) sought to compare BiVP versus RVP in patients with symptomatic heart failure (HF) and atrioventricular (AV) block. Methods and Results: COMBAT is a prospective multicenter randomized double blind crossover study. Patients with New York Heart Association functional class (FC) II-IV, left ventricular ejection fraction (LVEF) <40%, and AV block as an indication for pacing were enrolled. All patients underwent biventricular system implantation and then ...
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