Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. In the heart, the expression of OPN protein is increased after acute and chronic pathologies. Upregulation of OPN coincides with a transition to heart failure and a direct role for OPN in the progression of diabetic cardiomyopathy to heart failure has been reported. The overall objective of this project is to determine if OPN is upregulated in the heart in a model of type 2 diabetes and if OPN is increased in cardiac cells in response to high glucose...
Osteopontin (OPN) is a phosphoglycoprotein of cardiac extracellular matrix and it is still poorly de...
Objective: Test the role of osteopontin in anti-fibrotic β2AR signaling in cardiac myocytes. Backg...
Osteopontin (OPN) expression increases in the heart during hypertrophy and heart failure. Here, we s...
The purpose of this study was to investigate the role of osteopontin (OPN) in diabetic hearts. Diabe...
Cardiac remodelling refers to molecular and cellular changes of the myocardium, as well as adapting ...
Cardiovascular disease (CVD) is the leading cause of death in the United States. A common feature in...
Osteopontin (OPN) is involved in various physiological processes and also implicated in multiple pat...
Angiotensin II (A II) is a critical factor in cardiac remodeling which involves hypertrophy, fibrobl...
Osteopontin (OPN) is not expressed in healthy heart while, its expression is dramatically increased ...
International audienceBACKGROUND: Inflammatory processes play a critical role in myocarditis, dilate...
Cardiac β2-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in ...
Purpose: The morphological and molecular features of cardiac remodelling are similar in idiopathic (...
AbstractObjectivesOsteopontin (OPN) is upregulated in left ventricular hypertrophy and is stimulated...
Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological pro...
Cardiovascular disease is one of the leading causes of death in the elderly. Much of the morbidity a...
Osteopontin (OPN) is a phosphoglycoprotein of cardiac extracellular matrix and it is still poorly de...
Objective: Test the role of osteopontin in anti-fibrotic β2AR signaling in cardiac myocytes. Backg...
Osteopontin (OPN) expression increases in the heart during hypertrophy and heart failure. Here, we s...
The purpose of this study was to investigate the role of osteopontin (OPN) in diabetic hearts. Diabe...
Cardiac remodelling refers to molecular and cellular changes of the myocardium, as well as adapting ...
Cardiovascular disease (CVD) is the leading cause of death in the United States. A common feature in...
Osteopontin (OPN) is involved in various physiological processes and also implicated in multiple pat...
Angiotensin II (A II) is a critical factor in cardiac remodeling which involves hypertrophy, fibrobl...
Osteopontin (OPN) is not expressed in healthy heart while, its expression is dramatically increased ...
International audienceBACKGROUND: Inflammatory processes play a critical role in myocarditis, dilate...
Cardiac β2-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in ...
Purpose: The morphological and molecular features of cardiac remodelling are similar in idiopathic (...
AbstractObjectivesOsteopontin (OPN) is upregulated in left ventricular hypertrophy and is stimulated...
Osteopontin (OPN) is recognized for its significant roles in both physiological and pathological pro...
Cardiovascular disease is one of the leading causes of death in the elderly. Much of the morbidity a...
Osteopontin (OPN) is a phosphoglycoprotein of cardiac extracellular matrix and it is still poorly de...
Objective: Test the role of osteopontin in anti-fibrotic β2AR signaling in cardiac myocytes. Backg...
Osteopontin (OPN) expression increases in the heart during hypertrophy and heart failure. Here, we s...