Add to ORKGA series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives were synthesized and tested for in vitro leishmanicidal activity against amastigotes of Leishmania amazonensis in axenical cultures and murine infected macrophages. Structure-activity relationships demonstrated the importance of a radical methoxy at position R3', R4' and R5'. (2E)-3-(3,4,5-trimethoxy-phenyl)-1-(3,6,7-trimethyl-1,4-dioxy-quinoxalin-2-yl)-propenone was the most active. Cytotoxicity on macrophages revealed that this product was almost six times more active than toxic
Currently available drugs being used to treat leishmaniasis have several shortcomings, including hig...
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to...
International audienceAn antileishmanial pharmacomodulation at position 4 of 8-nitroquinolin-2(1H)-o...
A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives ...
A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives ...
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania...
Naphtoquinones have been used as promising scaffolds for drug design studies against protozoan paras...
Quinoline derivatives and especially quinolones are considered as privileged structures in medicinal...
Naphtoquinones have been used as promising scaffolds for drug design studies against protozoan paras...
Two series of pyrazol and propenone quinoxaline derivatives were tested for parasiticidal activity (...
International audienceFrom a recently identified antileishmanial pharmacophore, a structure activity...
Leishmaniasis is a neglected, parasitic tropical disease caused by an intracellular protozoan from t...
International audienceMalaria and leishmaniasis are two of the World’s most important tropical paras...
In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a...
Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continu...
Currently available drugs being used to treat leishmaniasis have several shortcomings, including hig...
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to...
International audienceAn antileishmanial pharmacomodulation at position 4 of 8-nitroquinolin-2(1H)-o...
A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives ...
A series of ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives ...
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania...
Naphtoquinones have been used as promising scaffolds for drug design studies against protozoan paras...
Quinoline derivatives and especially quinolones are considered as privileged structures in medicinal...
Naphtoquinones have been used as promising scaffolds for drug design studies against protozoan paras...
Two series of pyrazol and propenone quinoxaline derivatives were tested for parasiticidal activity (...
International audienceFrom a recently identified antileishmanial pharmacophore, a structure activity...
Leishmaniasis is a neglected, parasitic tropical disease caused by an intracellular protozoan from t...
International audienceMalaria and leishmaniasis are two of the World’s most important tropical paras...
In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a...
Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continu...
Currently available drugs being used to treat leishmaniasis have several shortcomings, including hig...
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to...
International audienceAn antileishmanial pharmacomodulation at position 4 of 8-nitroquinolin-2(1H)-o...