Add to ORKGMalaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirteen new 2-cyano-3-(4-phenylpiperazine-1-carboxamido) quinoxaline 1,4-dioxide derivatives (CPCQs) were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against erythrocytic forms of Plasmodium falciparum and axenic forms of Leishmania infantum. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. None of the tested compounds was efficient against Plasmodium, but two of them showed good activity against Leishmania. Toxicity on VERO was correlated with leishmanicidal properties
As a part of our project aimed at developing new safe chemotherapeutic agents against tropical disea...
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania...
Leishmaniasis is a neglected, parasitic tropical disease caused by an intracellular protozoan from t...
International audienceMalaria and leishmaniasis are two of the World's most important tropical paras...
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirte...
International audienceMalaria and leishmaniasis are two of the World’s most important tropical paras...
Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continu...
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continu...
Malaria is by far the world¿s most important tropical parasitic disease and one of the oldest diseas...
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fou...
International audienceThe multistep synthesis of new quinazoline-derived molecules and their in vitr...
International audienceWe report the design (in silico ADMET criteria), synthesis, cytotoxicity studi...
Cutaneous leishmaniasis and Chagas disease are vector-borne parasitic disease causing serious risks ...
We report the design (in silico ADMET criteria), synthesis, cytotoxicity studies (HepG-2 cells), and...
International audienceFrom three previously identified antiplasmodial hit compounds (A-C) and inacti...
As a part of our project aimed at developing new safe chemotherapeutic agents against tropical disea...
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania...
Leishmaniasis is a neglected, parasitic tropical disease caused by an intracellular protozoan from t...
International audienceMalaria and leishmaniasis are two of the World's most important tropical paras...
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Thirte...
International audienceMalaria and leishmaniasis are two of the World’s most important tropical paras...
Malaria and leishmaniasis are two of the World's most important tropical parasitic diseases. Continu...
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continu...
Malaria is by far the world¿s most important tropical parasitic disease and one of the oldest diseas...
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fou...
International audienceThe multistep synthesis of new quinazoline-derived molecules and their in vitr...
International audienceWe report the design (in silico ADMET criteria), synthesis, cytotoxicity studi...
Cutaneous leishmaniasis and Chagas disease are vector-borne parasitic disease causing serious risks ...
We report the design (in silico ADMET criteria), synthesis, cytotoxicity studies (HepG-2 cells), and...
International audienceFrom three previously identified antiplasmodial hit compounds (A-C) and inacti...
As a part of our project aimed at developing new safe chemotherapeutic agents against tropical disea...
Pyrazole and propenone quinoxaline derivatives were tested against intracellular forms of Leishmania...
Leishmaniasis is a neglected, parasitic tropical disease caused by an intracellular protozoan from t...