Traces of activated factor VII (FVIIa) are required to maintain haemostasis. Activated factor X (FXa) is the main activator of FVII in the absence of tissue factor. However, little is known about how this mechanism is regulated. We and others reported the interaction between FVII and the endothelial cell protein C receptor (EPCR). We have analysed the role of EPCR in the FXa-dependent FVIIa generation. Activation was performed on the surface of human aortic endothelial cells in the presence or absence of a blocking anti-EPCR monoclonal antibody (mAb). Western-blot analyses revealed that FVII activation was increased twofold upon EPCR blocking. Kinetic analyses revealed that blocking doubled the catalytic efficiency for activation. Protein C...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
Uniquely amongst vitamin K-dependent coagulation proteins, protein C interacts via its Gla domain bo...
Endothelial cell protein C receptor (EPCR), a multifunctional and multicellular receptor, is known t...
Traces of activated factor VII (FVIIa) are required to maintain haemostasis. Activated factor X (FXa...
BACKGROUND: Endothelial cell protein C receptor (EPCR) binds protein C through its gamma-carboxyglut...
Background: Recent studies show that FVIIa binds to endothelial cell protein C receptor (EPCR) on va...
factor VII (FVIIa) binds to the endothelial cell protein C receptor (EPCR) on the vascular endotheli...
Recent in vitro studies have shown that the zymogen and activated form of factor (F)VII bind to endo...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received ...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
The endothelial protein C receptor (EPCR) plays an anticoagulant role by improving protein C activat...
The endothelial protein C receptor (EPCR) plays an anticoagulant role by improving protein C activat...
Endothelial cell protein C receptor (EPCR) downregulates the coagulation system and prevents thrombo...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
Uniquely amongst vitamin K-dependent coagulation proteins, protein C interacts via its Gla domain bo...
Endothelial cell protein C receptor (EPCR), a multifunctional and multicellular receptor, is known t...
Traces of activated factor VII (FVIIa) are required to maintain haemostasis. Activated factor X (FXa...
BACKGROUND: Endothelial cell protein C receptor (EPCR) binds protein C through its gamma-carboxyglut...
Background: Recent studies show that FVIIa binds to endothelial cell protein C receptor (EPCR) on va...
factor VII (FVIIa) binds to the endothelial cell protein C receptor (EPCR) on the vascular endotheli...
Recent in vitro studies have shown that the zymogen and activated form of factor (F)VII bind to endo...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
In the last decade, the endothelial cell protein C/activated protein C receptor (EPCR) has received ...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
The endothelial protein C receptor (EPCR) plays an anticoagulant role by improving protein C activat...
The endothelial protein C receptor (EPCR) plays an anticoagulant role by improving protein C activat...
Endothelial cell protein C receptor (EPCR) downregulates the coagulation system and prevents thrombo...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
Recent studies have suggested that antithrombin (AT) could act as a significant physiologic regulato...
Uniquely amongst vitamin K-dependent coagulation proteins, protein C interacts via its Gla domain bo...
Endothelial cell protein C receptor (EPCR), a multifunctional and multicellular receptor, is known t...