In recent years, it became possible to perform very well controlled experiments that have shown a violation of the no-slip boundary condition in sub-micron sized geometries. Since then, mostly experimental, but also theoretical works, as well as computer simulations, have been performed to improve our understanding of boundary slip. The topic is of fundamental interest because it has practical consequences in the physical and engineering sciences as well as for medical and industrial applications. This work focuses on numerical investigations of the slip phenomenon by means of lattice Boltzmann simulations with a strong focus on roughness and the interplay between roughness and wetting phenomena. To do so, two different slip measurement m...