In this study we have demonstrated in a murine model of allergic airway inflammation that intranasal infection with the human pathogen M. catarrhalis exacerbate pulmonary inflammation. The aim of the study was: i) to establish an animal model of infection induced exacerbation of lung allergic reactions, ii) to study the pulmonary immune responses of HDM allergic animals with and without infection and iii) to identify potential targets to prevent exacerbation of lung inflammation. The essential findings are that the human pathogen, M. catarrhalis, is able to colonize murine lungs for approximately 6 days and thus can be used as a model germ for acute respiratory infection. We further could show, that infection with M. catarrhalis ex...
<p>Mice were vaccinated (1 dose per week, 4 doses in total) with either the adjuvant cholera toxin a...
A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflamma...
Cytokines are important soluble signalling molecules that dictate and coordinate inflammatory and im...
In this study we have demonstrated in a murine model of allergic airway inflammation that intranasa...
Alterations of the airway microbiome are often associated with pulmonary diseases. For example, dete...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been ass...
AbstractVirus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary en...
Thesis (Ph.D.)--University of Washington, 2016-03Human asthma is a heterogeneous disease characteriz...
Thesis (Ph.D.)--University of Washington, 2016-03Human asthma is a heterogeneous disease characteriz...
In patients with chronic obstructive pulmonary disease (COPD), Moraxella catarrhalis infection of th...
Accumulating evidence suggests that two chronic respiratory diseases, nontuberculous mycobacterium (...
Research Doctorate - Doctor of Philosophy (PhD)Activation of innate immune responses in individuals ...
<p>Mice were vaccinated (1 dose per week, 4 doses in total) with either the adjuvant cholera toxin a...
A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflamma...
Cytokines are important soluble signalling molecules that dictate and coordinate inflammatory and im...
In this study we have demonstrated in a murine model of allergic airway inflammation that intranasa...
Alterations of the airway microbiome are often associated with pulmonary diseases. For example, dete...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
The pathophysiological mechanisms driving exaggerated inflammation and tissue damage, associated to ...
RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been ass...
AbstractVirus infection may contribute to asthma pathogenesis. In turn, a Th2-polarized pulmonary en...
Thesis (Ph.D.)--University of Washington, 2016-03Human asthma is a heterogeneous disease characteriz...
Thesis (Ph.D.)--University of Washington, 2016-03Human asthma is a heterogeneous disease characteriz...
In patients with chronic obstructive pulmonary disease (COPD), Moraxella catarrhalis infection of th...
Accumulating evidence suggests that two chronic respiratory diseases, nontuberculous mycobacterium (...
Research Doctorate - Doctor of Philosophy (PhD)Activation of innate immune responses in individuals ...
<p>Mice were vaccinated (1 dose per week, 4 doses in total) with either the adjuvant cholera toxin a...
A subset of patients with stable asthma has prominent neutrophilic and reduced eosinophilic inflamma...
Cytokines are important soluble signalling molecules that dictate and coordinate inflammatory and im...