Add to ORKGActivity based protein profiling (ABPP) is a functional proteomic technology that uses chemical probes to detect mechanistically related classes of enzymes. Chemically probing a certain class of proteins helps to understand their biological function as a group, and discover new biosynthetic pathways for drug design. This research describes two activity based proteomic methods that have been developed to probe and identify sulfur carrier proteins and vitamin B6 dependent proteins, respectively. Sulfur carrier proteins are small proteins (<10 kDa) involved in pathways for efficient sulfur delivery. A chemical probe with sulfonyl-azide functional group was designed to label and identify the sulfur carrier proteins through a thioacid-azide rea...
A cell can modulate the level of protein activity by the regulation of the amount of protein. On the...
Vitamins are, by definition, required for maintaining the health of the mammalian body. Vitamin E, w...
Streptomycetes, as nonmotile microbes, are forced to adapt to environmental conditions they cannot e...
Activity based protein profiling (ABPP) is a functional proteomic technology that uses chemical prob...
Protein oxidation is not a fully-understood concept in biology, where the identity of proteins conta...
A xanthene-BODIPY cassette is used as a ratiometric intracellular pH reporter for imaging protein-dy...
Determining the identity of prodrug activating enzyme(s) is key to understanding the mechanistic bas...
There is evidence that amyloid-beta (Aβ) toxicity is mediated through interactions and binding with ...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Includes bibliographi...
A previous study identified Enterococcus faecalis as one of two bacteria known to have the selD gene...
abstract: Exposure of blood plasma/serum (P/S) to thawed conditions, greater than -30°C, can produce...
Pyridoxal kinase (PL kinase) and pyridoxine 5’-phosphate oxidase (PNP oxidase) are the two vitamin B...
X-ray crystallography is the gold standard method for imagining macromolecules to atomic resolution....
Diatoms are unicellular photosynthetic algae that display intricately patterned cell walls made of a...
Iron-sulfur (Fe-S) clusters are cofactors that are required for many biological processes. Conserved...
A cell can modulate the level of protein activity by the regulation of the amount of protein. On the...
Vitamins are, by definition, required for maintaining the health of the mammalian body. Vitamin E, w...
Streptomycetes, as nonmotile microbes, are forced to adapt to environmental conditions they cannot e...
Activity based protein profiling (ABPP) is a functional proteomic technology that uses chemical prob...
Protein oxidation is not a fully-understood concept in biology, where the identity of proteins conta...
A xanthene-BODIPY cassette is used as a ratiometric intracellular pH reporter for imaging protein-dy...
Determining the identity of prodrug activating enzyme(s) is key to understanding the mechanistic bas...
There is evidence that amyloid-beta (Aβ) toxicity is mediated through interactions and binding with ...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.Includes bibliographi...
A previous study identified Enterococcus faecalis as one of two bacteria known to have the selD gene...
abstract: Exposure of blood plasma/serum (P/S) to thawed conditions, greater than -30°C, can produce...
Pyridoxal kinase (PL kinase) and pyridoxine 5’-phosphate oxidase (PNP oxidase) are the two vitamin B...
X-ray crystallography is the gold standard method for imagining macromolecules to atomic resolution....
Diatoms are unicellular photosynthetic algae that display intricately patterned cell walls made of a...
Iron-sulfur (Fe-S) clusters are cofactors that are required for many biological processes. Conserved...
A cell can modulate the level of protein activity by the regulation of the amount of protein. On the...
Vitamins are, by definition, required for maintaining the health of the mammalian body. Vitamin E, w...
Streptomycetes, as nonmotile microbes, are forced to adapt to environmental conditions they cannot e...