Each member of the protein kinase C (PKC) family activates cell signaling pathways with different and sometimes opposing cell functions, such as cell division, migration, or death. Because of the importance of these processes in human diseases and disorders like cancer, stroke, and Alzheimer’s disease, there is a need for drugs which modify the action of PKC. However, drug design is difficult due to the complicated nature of PKC regulation. To better understand the differential regulation of PKC activity, these studies probe the structure, dynamics, and reactivity of one of the domains responsible for PKC regulation, C1B. C1B binds signaling molecules and translocates PKC to membranes in order to release the kinase domain from inhibiti...
Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs, with two C1 d...
Protein kinase C (PKC) has a central role in responding to signals that cause lipid hydrolysis leadi...
AbstractBackground: The protein kinase C (PKC) family of lipid-dependent serine/threonine kinases pl...
Protein kinase C (PKC) isoenzymes sit in the crossroad of numerous signaling pathways involved in ce...
Protein Kinase C (PKC) family of isoenzymes are critical players in signal transduction at the membr...
It has been previously shown that activation of PKCα on the leading edge membrane of a polarized che...
AbstractTo explore the relative roles of the two C1 domains of protein kinase C alpha (PKCα) in the ...
Protein kinase C (PKC) is a critical component of many signaling pathways. As such, PKC regulates su...
In this issue of Chemistry & Biology, Antal and colleagues describe how phosphorylation optimizes th...
SummaryThe signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption...
The regulatory domains of conventional and novel protein kinases C (PKC) have two C1 domains (C1A an...
The regulatory domains of novel protein kinases C (PKC) contain two C1 domains (C1A and C1B), which ...
AbstractProtein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with m...
Protein Kinase C (PKC) isoforms function in signaling pathways responsible for controlling cell prol...
Protein kinase C theta (PKCθ) is a serine threonine kinase, which is predominantly expressed in the ...
Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs, with two C1 d...
Protein kinase C (PKC) has a central role in responding to signals that cause lipid hydrolysis leadi...
AbstractBackground: The protein kinase C (PKC) family of lipid-dependent serine/threonine kinases pl...
Protein kinase C (PKC) isoenzymes sit in the crossroad of numerous signaling pathways involved in ce...
Protein Kinase C (PKC) family of isoenzymes are critical players in signal transduction at the membr...
It has been previously shown that activation of PKCα on the leading edge membrane of a polarized che...
AbstractTo explore the relative roles of the two C1 domains of protein kinase C alpha (PKCα) in the ...
Protein kinase C (PKC) is a critical component of many signaling pathways. As such, PKC regulates su...
In this issue of Chemistry & Biology, Antal and colleagues describe how phosphorylation optimizes th...
SummaryThe signaling output of protein kinase C (PKC) is exquisitely controlled, with its disruption...
The regulatory domains of conventional and novel protein kinases C (PKC) have two C1 domains (C1A an...
The regulatory domains of novel protein kinases C (PKC) contain two C1 domains (C1A and C1B), which ...
AbstractProtein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with m...
Protein Kinase C (PKC) isoforms function in signaling pathways responsible for controlling cell prol...
Protein kinase C theta (PKCθ) is a serine threonine kinase, which is predominantly expressed in the ...
Protein kinase C-α (PKCα) has been studied widely as a paradigm for conventional PKCs, with two C1 d...
Protein kinase C (PKC) has a central role in responding to signals that cause lipid hydrolysis leadi...
AbstractBackground: The protein kinase C (PKC) family of lipid-dependent serine/threonine kinases pl...