Cell-penetrating peptides (CPPs) mediate the delivery of macromolecules across the plasma membrane of live cells. These peptides are therefore important due to the potential of making the delivery of protein probes or therapeutics a routine procedure. However, CPP-mediated delivery is currently an inefficient process. CPP-protein conjugates are internalized into cells by endocytosis and the macromolecules remain trapped inside endosomes instead of reaching the target cellular localization. To solve this problem, we report a delivery methodology which relies on the use of a chimera of the TAT and of the Influenza HA2. TAT is a prototypical CPP that can promote macropinocytosis in live cells and HA2 is a pH-sensitive peptide that destabilizes...
The anionic plasma membrane is generally refractory to passive extracellular-to-cytoplasmic transit ...
Over the last decade a number of peptides that are rapidly internalized by mammalian cells have been...
Cell-penetrating peptides (CPPs) have the potential to deliver a host of macromolecular therapeutics...
Cell-penetrating peptides (CPPs) enter cells primarily through escaping from endosomal compartments ...
The effective delivery of hydrophilic, bioactive molecules, such as enzymes and nucleic acids, to th...
Endocytosis has been proposed as one of the primary mechanisms for cellular entry of cell-penetratin...
Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targ...
Many biologically active compounds, including macromolecules that are used as various kinds of drugs...
The direct intracellular delivery of proteins has, until recently, been difficult to achieve, due pr...
Cell-penetrating peptides (CPPs) can induce translocation of conjugated macromolecules across the pl...
For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting ...
The major limitation in the application of bioactive molecule is their low permeation across pl...
Cell-penetrating peptides (CPPs) represent a noninvasive method for delivering functional biomolecul...
AbstractCell-penetrating peptides (CPPs) constitute a family of peptides with the characteristic abi...
Cell penetrating peptides (CPPs) have received considerable attention as cellular delivery vectors ...
The anionic plasma membrane is generally refractory to passive extracellular-to-cytoplasmic transit ...
Over the last decade a number of peptides that are rapidly internalized by mammalian cells have been...
Cell-penetrating peptides (CPPs) have the potential to deliver a host of macromolecular therapeutics...
Cell-penetrating peptides (CPPs) enter cells primarily through escaping from endosomal compartments ...
The effective delivery of hydrophilic, bioactive molecules, such as enzymes and nucleic acids, to th...
Endocytosis has been proposed as one of the primary mechanisms for cellular entry of cell-penetratin...
Protein therapy holds great promise for treating a variety of diseases. To act on intracellular targ...
Many biologically active compounds, including macromolecules that are used as various kinds of drugs...
The direct intracellular delivery of proteins has, until recently, been difficult to achieve, due pr...
Cell-penetrating peptides (CPPs) can induce translocation of conjugated macromolecules across the pl...
For over 20 years, cell-penetrating peptides (CPPs) have been used as delivery vectors transporting ...
The major limitation in the application of bioactive molecule is their low permeation across pl...
Cell-penetrating peptides (CPPs) represent a noninvasive method for delivering functional biomolecul...
AbstractCell-penetrating peptides (CPPs) constitute a family of peptides with the characteristic abi...
Cell penetrating peptides (CPPs) have received considerable attention as cellular delivery vectors ...
The anionic plasma membrane is generally refractory to passive extracellular-to-cytoplasmic transit ...
Over the last decade a number of peptides that are rapidly internalized by mammalian cells have been...
Cell-penetrating peptides (CPPs) have the potential to deliver a host of macromolecular therapeutics...