Genome scanning by composite likelihood

Dr. Collins is Head of the research group in Genetic Epidemiology and Bioinformatics at the University of Southampton. His current research focus is on the construction and integration of genetic maps and their application to disease gene mapping. In recent years the group has been concerned with the construction of linkage maps and integration with physical, and now sequence-based, maps. For this reason the genetic location database was developed (http://cedar.genetics.soton.ac.uk/public_html/LDB2003.html). The integrated maps have been useful in the positional cloning of major disease genes but the interest has now shifted to mapping genes for common diseases, such as asthma and heart disease. The group is currently developing novel approaches for linkage disequilibrium mapping exploiting metric linkage disequilibrium maps