Add to ORKGManipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. Remarkably, AA manipulation can uncouple the commonly observed trade-off between these traits. This finding seems to challenge the idea that this trade- off is due to competitive resource allocation, but here we argue that this view might be too simplistic. We also discuss the mechanisms of the AA response, mediated by the IIS/TOR and GCN2 pathways. Elucidating how these pathways respond to specific AA will likely yield important insights into how AA modulate the reproduction-lifespan relationship. The Drosophila model offers powerful genetic tools, combined with options for precise diet manipulation, to address these fundamental questi...
Dietary restriction extends healthy lifespan in diverse organisms but reduces fecundity; this is tho...
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of Targe...
The mechanisms through which dietary restriction enhances health and longevity in diverse species ar...
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. R...
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. R...
Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity. It is widel...
Dietary restriction (DR) is one of the most potent ways to extend health- and lifespan. Key progress...
Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acid...
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of TOR s...
Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents ...
Dietary restriction extends healthy lifespan in diverse organisms but reduces fecundity; this is tho...
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of Targe...
The mechanisms through which dietary restriction enhances health and longevity in diverse species ar...
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. R...
Manipulating amino acid (AA) intake in Drosophila can profoundly affect lifespan and reproduction. R...
Dietary restriction extends healthy lifespan in diverse organisms and reduces fecundity. It is widel...
Dietary restriction (DR) is one of the most potent ways to extend health- and lifespan. Key progress...
Dietary restriction promotes longevity but impairs fecundity in many organisms. When the amino acid...
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of TOR s...
Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
In most organisms, dietary restriction (DR) increases lifespan. However, several studies have found ...
Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents ...
Dietary restriction extends healthy lifespan in diverse organisms but reduces fecundity; this is tho...
Branched-chain amino acids (BCAAs) have been suggested to be particularly potent activators of Targe...
The mechanisms through which dietary restriction enhances health and longevity in diverse species ar...