peer reviewedController area network (CAN) has been the de facto standard in the automotive industry for the past two decades. Recently, CAN with flexible data-rate (CAN FD) has been standardized, which achieves noticeably higher throughput. Further improvements are still possible for CAN, by exploiting its peculiar physical layer to carry out distributed operations among network nodes, implemented as atomic transactions mapped on quasi-conventional frame exchanges. In this paper, a proposal is made for an extension to the CAN protocol, termed CAN with eXtensible in-frame Reply (CAN XR), which enables upper protocol layers to define new custom services devoted to, e.g., network management, application-specific functions, and high-efficiency...