Bioactive scaffolds with multifunctional properties for hard tissue regenerations

The impact of bone/dental diseases and trauma in the whole world has increased significantly in the past decades. It is of great importance to develop bioactive scaffolds with multifunctional properties, such as osteogenesis, angiogenesis, cementogenesis, drug delivery and antibacterial property for hard tissue regeneration. Conventional bioactive scaffolds cannot efficiently combine these functions. A new class of bioactive glass, referred to as mesoporous bioactive glass (MBG), was developed several years ago, which possesses highly ordered mesoporous channel structure and high-specific surface area. Due to their special nanostructure, MBG scaffolds show multifunctional potential for hard tissue regeneration application. In this chapter, we review the recent research advances of multifunctional MBG scaffolds, including the preparation of different forms of MBG scaffolds, osteogenesis, angiogenesis, cementogenesis, drug delivery and antibacterial property. The future perspective of MBG scaffolds was further discussed for hard tissue regeneration application by harnessing their special multifunction