We propose an invariant see-saw (ISS) approach to model building, based on the observation that see-saw models of neutrino mass and mixing fall into basis invariant classes labelled by the Casas–Ibarra R-matrix, which we prove to be invariant not only under basis transformations but also non-unitary right-handed neutrino transformations S. According to the ISS approach, given any see-saw model in some particular basis one may determine the invariant R-matrix and hence the invariant class to which that model belongs. The formulation of see-saw models in terms of invariant classes puts them on a firmer theoretical footing, and allows different see-saw models in the same class to be related more easily, while their relation to the R-matrix mak...