Spatially controlled surface immobilization of nonmodified peptides
- Pauloehrl, T.
- Welle, A.
- Bruns, M.
- Linkert, K.
- Börner, H. G.
- Bastmeyer, M.
- Delaittre, G.
- Barner-Kowollik, C.
DOIAbstract
A phencyclone derivative is used to achieve light-controlled immobilization of peptides possessing only natural amino acids. The photoactive precursor (blue in picture) is formed in a Diels-Alder reaction and can undergo light-triggered ring-opening reactions with amines. Successful surface patterning with a genuine c(RGDfK) peptide (green) is evidenced by imaging time-of-flight secondary-ion mass spectrometry (ToF-SIMS). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
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