This research designed and synthesised novel dual action cardio-protective agents combining with nitroxides possessing antioxidant properties. The work resulted in the discovery of a new generation of chemical compounds which can act on more than one targeted disease. This new generation multi-targeted drug compounds can have benefits in reducing toxicity and side effects. The synthesised drug compounds could potentially act as effective preventive treatments for inflammatory diseases and also provide cardiovascular protection
The present invention relates to the field of pharmaceuticals. In particular, it relates to new com...
The new technology of combinational chemistry has been introduced to pharmaceutical companies, impro...
Oxidants play role in many diseases. It is therefore not a complete surprise that many registered dr...
This research designed and synthesised novel dual action cardio-protective agents combining with nit...
This project employed a rational drug design and development approached to make hybrid dual-acting a...
Dual-acting hybrid anti-oxidant/anti-inflammatory agents were developed employing the principle of p...
Background: Several different strategies are commonly used in medicinal chemistry to develop new mol...
In this study, a new class of phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates was desi...
Atherosclerosis is a cardiovascular disease which forms plaques which narrow the arteries, restricti...
Cardiovascular disease represents the main cause of death worldwide. Novel therapies to reduce eleva...
The pharmacotherapy of complex pathological states at the cardiovascular level often requires differ...
The objective of this research was to produce single chemical entities with dual pharmacological act...
Some mexiletine derivatives with isoindoline based antioxidants attached have been shown to have sig...
The design of compounds able to combine the selective inhibition of cyclooxygenase-2 (COX-2) with th...
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported....
The present invention relates to the field of pharmaceuticals. In particular, it relates to new com...
The new technology of combinational chemistry has been introduced to pharmaceutical companies, impro...
Oxidants play role in many diseases. It is therefore not a complete surprise that many registered dr...
This research designed and synthesised novel dual action cardio-protective agents combining with nit...
This project employed a rational drug design and development approached to make hybrid dual-acting a...
Dual-acting hybrid anti-oxidant/anti-inflammatory agents were developed employing the principle of p...
Background: Several different strategies are commonly used in medicinal chemistry to develop new mol...
In this study, a new class of phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates was desi...
Atherosclerosis is a cardiovascular disease which forms plaques which narrow the arteries, restricti...
Cardiovascular disease represents the main cause of death worldwide. Novel therapies to reduce eleva...
The pharmacotherapy of complex pathological states at the cardiovascular level often requires differ...
The objective of this research was to produce single chemical entities with dual pharmacological act...
Some mexiletine derivatives with isoindoline based antioxidants attached have been shown to have sig...
The design of compounds able to combine the selective inhibition of cyclooxygenase-2 (COX-2) with th...
The development of a novel class of pharmacodynamic hybrids that inhibits COX-2 isoform is reported....
The present invention relates to the field of pharmaceuticals. In particular, it relates to new com...
The new technology of combinational chemistry has been introduced to pharmaceutical companies, impro...
Oxidants play role in many diseases. It is therefore not a complete surprise that many registered dr...