Factors influencing quality of life in patients with benign primary brain tumors : prior to and following surgery

Goals: Few studies have repeatedly evaluated quality of life\ud and potentially relevant factors in patients with benign\ud primary brain tumor. The purpose of this study was to\ud explore the relationship between the experience of the\ud symptom distress, functional status, depression, and quality\ud of life prior to surgery (T1) and 1 month post-discharge\ud (T2). ----------\ud Patients and methods: This was a prospective cohort study\ud including 58 patients with benign primary brain tumor in\ud one teaching hospital in the Taipei area of Taiwan. The\ud research instruments included the M.D. Anderson Symptom\ud Inventory, the Functional Independence Measure\ud scale, the Hospital Depression Scale, and the Functional\ud Assessment of Cancer Therapy-Brain.----------\ud Results: Symptom distress (T1: r=−0.90, p<0.01; T2:\ud r=−0.52, p<0.01), functional status (T1: r=0.56, p<0.01),\ud and depression (T1: r=−0.71, p<0.01) demonstrated a\ud significant relationship with patients' quality of life.\ud Multivariate analysis identified symptom distress\ud (explained 80.2%, Rinc 2=0.802, p=0.001) and depression\ud (explained 5.2%, Rinc 2=0.052, p