Add to ORKGThis thesis is aimed at providing an overview about the relevant role played in drug design by the knowledge, at a molecular level, of ligand (drug)-receptor (biological terget) interactions as well as paths that ligands should follow to reach their binding site(s) within the receptor. This research led at developing a basic approach for rational design of ligands, which are endowed of particular mechanisms, that is bivalent ligands and allosteric modulators, of interaction with the receptor of interest
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Recent advances in structural biology and computational techniques have revealed allosteric mechanis...
Ligand-protein and protein-protein interactions play a pivotal role in any cellular process and func...
Allosteric receptor ligands bind to a recognition site that is distinct from the binding site of the...
Dualsteric ligands represent a novel mode of targeting G protein-coupled receptors. These compounds ...
Dualsteric ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These c...
G protein-coupled receptors (GPCRs) are one of the most important classes of proteins in the genome,...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Recent advances in structural biology and computational techniques have revealed allosteric mechanis...
Ligand-protein and protein-protein interactions play a pivotal role in any cellular process and func...
Allosteric receptor ligands bind to a recognition site that is distinct from the binding site of the...
Dualsteric ligands represent a novel mode of targeting G protein-coupled receptors. These compounds ...
Dualsteric ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These c...
G protein-coupled receptors (GPCRs) are one of the most important classes of proteins in the genome,...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Allosteric interactions play vital roles in metabolic processes and signal transduction and, more re...
Recent advances in structural biology and computational techniques have revealed allosteric mechanis...
Ligand-protein and protein-protein interactions play a pivotal role in any cellular process and func...