Add to ORKGObjective: To compare plasma morphine concentration\u96time profiles following intranasal and intravenous diamorphine administration. Design: Observational. Setting: A&E department in a city-centre paediatric teaching hospital. Patients: Children, aged 3\u9613 years, with isolated limb fracture. Interventions: An intravenous catheter was sited and baseline blood taken. The first 12 children received intravenous diamorphine (0.1 mg/kg), and the subsequent 12 intranasal diamorphine (0.1 mg/kg) in 0.2 ml sterile water drops. Subsequent samples were taken at 2, 5, 10, 20, 30 and 60 min. Measurements: Plasma morphine radioimmunoassay. Results: Peak plasma morphine concentrations were higher (median 109 vs 36 nmol/l), and occurred earlier (...
AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of ch...
Background: oral morphine is frequently used for breakthrough pain but the oral route is not always ...
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hyp...
1 Comparison of morphine concentration-time profiles following intravenous and intranasal diamorphin...
Title of research: Differences in daily morphine dosage in the paediatric population according to ag...
Pharmacokinetic-pharmacodynamic modeling and simulation can facilitate understanding and prediction ...
Objectives : To assess the efficacy in pain relief, complication, practicality and patient's complia...
Objectives To establish the safety of an intranasal diamorphine (IND) spray in children. Design An o...
BACKGROUND: Oral morphine has been proposed as an effective and safe alternative to codeine for afte...
Titrating analgesic and sedative drugs in pediatric intensive care remains a challenge for caregiver...
OBJECTIVE: To 1) determine current intravenous (IV) acetaminophen use in pediatric inpatients; and 2...
Background: Children with sickle cell disease (SCD) frequently and unpredictably present to the emer...
BACKGROUND: Children with sickle cell disease (SCD) frequently and unpredictably present to the emer...
textabstractBACKGROUND: Descriptions of the pharmacokinetics and metabolism of morphine and it...
OBJECTIVE:To compare the pharmacodynamics and pharmacokinetics of IV morphine after cardiac surgery ...
AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of ch...
Background: oral morphine is frequently used for breakthrough pain but the oral route is not always ...
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hyp...
1 Comparison of morphine concentration-time profiles following intravenous and intranasal diamorphin...
Title of research: Differences in daily morphine dosage in the paediatric population according to ag...
Pharmacokinetic-pharmacodynamic modeling and simulation can facilitate understanding and prediction ...
Objectives : To assess the efficacy in pain relief, complication, practicality and patient's complia...
Objectives To establish the safety of an intranasal diamorphine (IND) spray in children. Design An o...
BACKGROUND: Oral morphine has been proposed as an effective and safe alternative to codeine for afte...
Titrating analgesic and sedative drugs in pediatric intensive care remains a challenge for caregiver...
OBJECTIVE: To 1) determine current intravenous (IV) acetaminophen use in pediatric inpatients; and 2...
Background: Children with sickle cell disease (SCD) frequently and unpredictably present to the emer...
BACKGROUND: Children with sickle cell disease (SCD) frequently and unpredictably present to the emer...
textabstractBACKGROUND: Descriptions of the pharmacokinetics and metabolism of morphine and it...
OBJECTIVE:To compare the pharmacodynamics and pharmacokinetics of IV morphine after cardiac surgery ...
AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of ch...
Background: oral morphine is frequently used for breakthrough pain but the oral route is not always ...
Objective: Morphine is a commonly used drug in encephalopathic neonates treated with therapeutic hyp...