We have examined the effects of widely used stress-inducing agents on protein synthesis and on regulatory components of the translational machinery. The three stresses chosen, arsenite, hydrogen peroxide and sorbitol, exert their effects in quite different ways. Nonetheless, all three rapidly (? 30 min) caused a profound inhibition of protein synthesis. In each case this was accompanied by dephosphorylation of the eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and increased binding of this repressor protein to eIF4E. Binding of 4E-BP1 to eIF4E correlated with loss of eIF4F complexes. Sorbitol and hydrogen peroxide each caused inhibition of the 70-kDa ribosomal protein S6 kinase, while arsenite activated it. The effects of ...
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing t...
Translation is a complex process essential for cell survival that is subjected to a strict regulatio...
The production of newly synthesized proteins is vital for all cellular functions and is a determinan...
We have examined the effects of widely used stress-inducing agents on protein synthesis and on regul...
To investigate the role for initiation factor phosphorylation in de novo translation, we have studie...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
Protein translational machinery is an important component of the proteostasis network that maintains...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed t...
Eukaryotic initiation factor (eIF) 4E binds to the 5'-cap structure of eukaryotic mRNA and has a cen...
<p>Identification of translation classes of mRNA. A) Analysis of the translation change after stress...
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed t...
Previous work has suggested that increased phosphorylation of eukaryotic initiation factor (eIF) 4E ...
Transient protein synthesis inhibition is an important protective mechanism used by cells during var...
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing t...
Translation is a complex process essential for cell survival that is subjected to a strict regulatio...
The production of newly synthesized proteins is vital for all cellular functions and is a determinan...
We have examined the effects of widely used stress-inducing agents on protein synthesis and on regul...
To investigate the role for initiation factor phosphorylation in de novo translation, we have studie...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
Protein translational machinery is an important component of the proteostasis network that maintains...
The protein kinase mammalian target of rapamycin (mTOR) regulates the phosphorylation and activity o...
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed t...
Eukaryotic initiation factor (eIF) 4E binds to the 5'-cap structure of eukaryotic mRNA and has a cen...
<p>Identification of translation classes of mRNA. A) Analysis of the translation change after stress...
Stress granules (SGs) are cytoplasmic foci at which untranslated mRNAs accumulate in cells exposed t...
Previous work has suggested that increased phosphorylation of eukaryotic initiation factor (eIF) 4E ...
Transient protein synthesis inhibition is an important protective mechanism used by cells during var...
Environmental stress-induced phosphorylation of eIF2alpha inhibits protein translation by reducing t...
Translation is a complex process essential for cell survival that is subjected to a strict regulatio...
The production of newly synthesized proteins is vital for all cellular functions and is a determinan...