Add to ORKGOBJECTIVES. We hypothesized that inhaled nitric oxide treatment of premature infants at risk for bronchopulmonary dysplasia would not adversely affect endogenous surfactant function or composition. METHODS. As part of the Nitric Oxide Chronic Lung Disease Trial of inhaled nitric oxide, we examined surfactant in a subpopulation of enrolled infants. Tracheal aspirate fluid was collected at specified intervals from 99 infants with birth weights <1250 g who received inhaled nitric oxide (20 ppm, weaned to 2 ppm) or placebo gas for 24 days. Large-aggregate surfactant was analyzed for surface activity with a pulsating bubble surfactometer and for surfactant protein contents with an immunoassay. RESULTS. At baseline, before administration of stu...
Surfactant kinetics in preterm infants on mechanical ventilation who did and did not develop broncho...
BackgroundIn animal models, inhaled nitric oxide improved gas exchange and lung structural developme...
OBJECTIVE. The goal was to establish whether reduced amounts of pulmonary surfactant contribute to p...
Pulmonary surfactant is routinely used in immature newborns for the prevention and treatment of resp...
BackgroundMany premature infants with respiratory failure are deficient in surfactant, but the relat...
Developmental deficiency in pulmonary surfactant leads to respiratory distress syndrome (RDS) in pre...
The function of pulmonary surfactant of a group of 14 preterm neonates (birth weight 907 +/- 60 g) w...
OBJECTIVE. We compared serial measurements of inflammatory mediators and markers in infants treated ...
ObjectiveTo assess whether late surfactant treatment in extremely low gestational age (GA) newborn i...
Aim: To test the hypothesis that inhaled nitric oxide therapy can decrease the incidence of bronchop...
Respiratory distress syndrome (RDS) still represents one of the main problems in the treatment of pr...
Inhaled nitric oxide is approved by FDA for the management of hypoxemic respiratory failure in term ...
Background In animal models, inhaled nitric oxide improved gas exchange and lung structural developm...
Objectives: To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely suppl...
textabstractBackground: Several concepts of treatment in neonatal ARDS have been proposed in the las...
Surfactant kinetics in preterm infants on mechanical ventilation who did and did not develop broncho...
BackgroundIn animal models, inhaled nitric oxide improved gas exchange and lung structural developme...
OBJECTIVE. The goal was to establish whether reduced amounts of pulmonary surfactant contribute to p...
Pulmonary surfactant is routinely used in immature newborns for the prevention and treatment of resp...
BackgroundMany premature infants with respiratory failure are deficient in surfactant, but the relat...
Developmental deficiency in pulmonary surfactant leads to respiratory distress syndrome (RDS) in pre...
The function of pulmonary surfactant of a group of 14 preterm neonates (birth weight 907 +/- 60 g) w...
OBJECTIVE. We compared serial measurements of inflammatory mediators and markers in infants treated ...
ObjectiveTo assess whether late surfactant treatment in extremely low gestational age (GA) newborn i...
Aim: To test the hypothesis that inhaled nitric oxide therapy can decrease the incidence of bronchop...
Respiratory distress syndrome (RDS) still represents one of the main problems in the treatment of pr...
Inhaled nitric oxide is approved by FDA for the management of hypoxemic respiratory failure in term ...
Background In animal models, inhaled nitric oxide improved gas exchange and lung structural developm...
Objectives: To examine whether exogenous pulmonary surfactants (exPS) substitute for or merely suppl...
textabstractBackground: Several concepts of treatment in neonatal ARDS have been proposed in the las...
Surfactant kinetics in preterm infants on mechanical ventilation who did and did not develop broncho...
BackgroundIn animal models, inhaled nitric oxide improved gas exchange and lung structural developme...
OBJECTIVE. The goal was to establish whether reduced amounts of pulmonary surfactant contribute to p...