Add to ORKGGlobozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mainly characterized by round-headed spermatozoa that lack an acrosome. It originates from a disturbed spermiogenesis, which is expected to be induced by a genetic factor. Several family cases and recessive mouse models with the same phenotype support this expectation. In this study, we present a consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition in humans caused by an autosomal gene defect, and it could also mean that the identification of other partners like SPATA16 could elucida...
AbstractInfertility, defined as the inability to conceive after 1year of unprotected intercourse, is...
International audienceGlobozoospermia is a rare phenotype of primary male infertility inducing the p...
Male infertility represents one of the clearest examples of a complex disease with a substantial gen...
Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mai...
Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mai...
A recent genetic analysis of infertile globozoospermic patients identified causative mutations in th...
A recent genetic analysis of infertile globozoospermic patients identified causative mutations in th...
aThese two authors contributed equally to this work. BACKGROUND: Globozoospermia is a severe form of...
Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoos...
BACKGROUND: The aetiology of human male fertility, with impairment of sperm number, motility and mor...
AbstractInfertility, defined as the inability to conceive after 1year of unprotected intercourse, is...
International audienceGlobozoospermia is a rare phenotype of primary male infertility inducing the p...
Male infertility represents one of the clearest examples of a complex disease with a substantial gen...
Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mai...
Globozoospermia is a rare (incidence <0.1% in male infertile patients) form of teratozoospermia, mai...
A recent genetic analysis of infertile globozoospermic patients identified causative mutations in th...
A recent genetic analysis of infertile globozoospermic patients identified causative mutations in th...
aThese two authors contributed equally to this work. BACKGROUND: Globozoospermia is a severe form of...
Globozoospermia is a rare (incidence <0.1%) but severe disorder in male infertility. Total globozoos...
BACKGROUND: The aetiology of human male fertility, with impairment of sperm number, motility and mor...
AbstractInfertility, defined as the inability to conceive after 1year of unprotected intercourse, is...
International audienceGlobozoospermia is a rare phenotype of primary male infertility inducing the p...
Male infertility represents one of the clearest examples of a complex disease with a substantial gen...