MicroRNAs control angiogenesis

The elegant report by Poliseno and colleagues indicates for the first time the functional role of microRNAs (miRNAs) in endothelial cells. Specifically, they identify miR-221 and miR-222 as key players in the control of angiogenesis, showing that they modulate the expression of kit receptor in human umbilical vein endothelial cells (HUVECs) and hence the angiogenic properties of the kit ligand, also called stem cell factor. ..