Clinical and Molecular Epidemiology of Staphylococcal Toxic Shock Syndrome in the United Kingdom
- Sharma, H.
- Smith, D.
- Turner, C.E.
- Game, L.
- Pichon, B.
- Hope, R.
- Hill, R.
- Kearns, A.
- Sriskandan, S.
DOIAbstract
Staphylococcal toxic shock syndrome (TSS) was originally described in menstruating women and linked to TSS toxin 1 (TSST-1)-producing Staphylococcus aureus. Using UK national surveillance data, we ascertained clinical, molecular and superantigenic characteristics of TSS cases. Average annual TSS incidence was 0.07/100,000 population. Patients with nonmenstrual TSS were younger than those with menstrual TSS but had the same mortality rate. Children <16 years of age accounted for 39% of TSS cases, most caused by burns and skin and soft tissue infections. Nonmenstrual TSS is now more common than menstrual TSS in the UK, although both types are strongly associated with the tst+ clonal complex (CC) 30 methicillin-sensitive S. aureus lineage, whi...
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