Distinguishing low frequency oscillations within the 1/f spectral behaviour of electromagnetic brain signals

Background:It has been acknowledged that the frequency spectrum of measured electromagnetic (EM) brain signals shows a decrease in power with increasing frequency. This spectral behaviour may lead to difficulty in distinguishing event-related peaks from ongoing brain activity in the electro- and magnetoencephalographic (EEG and MEG) signal spectra. This can become an issue especially in the analysis of low frequency oscillations (LFOs) - below 0.5 Hz - which are currently being observed in signal recordings linked with specific pathologies such as epileptic seizures or attention deficit hyperactivity disorder (ADHD), in sleep studies, etc. Methods:In this work we propose a simple method that can be used to compensate for this 1/f trend hence achieving spectral whitening. This method involves filtering the raw measured EM signal through a differentiator prior to further data analysis. Results:Applying the proposed method to various exemplary datasets including very low frequency EEG recordings, epileptic seizure recordings, MEG data and evoked response data showed that this compensating procedure provides a flat spectral base onto which event related peaks can be clearly observed.Conclusions:Findings suggest that the proposed filter is a useful tool for the analysis of physiological data especially in revealing very low frequency peaks which may otherwise be obscured by the 1/f spectral activity inherent in EEG/MEG recordings.