MESENTERIC LYMPH NODES IN SIMULATED RECTAL CANCER UNDER CONDITIONS OF CHEMOTHERAPY

The purpose of the study was to find out the typical morpho-functional changes in mesenteric lymph nodes of Wistar rats after modeling of rectal cancer and intraperitoneally injected cytostatic therapy with 5-fluorouracil and leucovorin. Malignant epithelial tumor (dimorphous cancer) invaded the wall of the rectum was detected 11 months after instillation of chemical carcinogens. Under conditions of tumor growth, significant changes in structural organization, activation of proliferative process and blast transformation in areas responsible for cellular and humoral immune response were found in mesenteric lymph nodes. Similar changes occurred against the background of intranodular redistribution of lymph to the cortical intermediate sinuses influencing on changes in cytoarchitectonics in areas responsible for detoxification processes and antitumor resistance. Under conditions of intraperitoneal injection of chemical agents, activity of proliferation and blast transformation in germinal centers and paracortical area was maintained, that, however, was followed by signs of suppression of immune responses in brain strands. Activation of indirect lymph flow and redistribution of lymph flow into cortical, intermediate and brain sinuses took place. Nonuniformity of structural transformations in 1 and 2 mesenteric lymph nodes related to different regions of lymph collection was noted. Increase in transport function of the mesenteric lymph nodes was observed