In the Peripheral nervous system (PNS), akin to the central, glial cells, Schwann cells and astrocytes, respectively, contain glycogen, which is glycolytically metabolised to lactate and transported to axons for oxidative metabolism. In the PNS, however, only the myelinated A fibres, not the unmyelinated C fibres, benefit. Using in vitro electrophysiology to simultaneously record A and C fibre conduction of the mouse sciatic nerve, I investigated the metabolic interactions between Schwann cells and axons, particularly during fructose metabolism.\ud Increased maintenance of A fibre conduction compared to C fibres in the absence of energy substrate confirmed that A fibres benefit from glycogen-derived lactate. Metabolic inhibitors, iodoacetat...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated ...
In the Peripheral nervous system (PNS), akin to the central, glial cells, Schwann cells and astrocyt...
Astrocytes of the central nervous system (CNS) provide glycogen derived lactate to axons when energy...
The ability of sciatic nerve A fibres to conduct action potentials relies on an adequate supply of e...
Central white matter and peripheral nerves function by conducting action potentials, which rely on t...
The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an ...
International audienceWhile lactate shuttle theory states that glial cells metabolize glucose into l...
It is hypothesized that L-lactate derived from astrocyte glycogen sustains axon excitability in mous...
The role of glycogen in the central nervous system is intimately linked with the glycolytic pathway....
We asked whether, in a steady state, neurons and glial cells both take up glucose sufficient for the...
C. Vega in the Neurobiologie des processus adaptatifs laboratory from 2002International audienceWe a...
In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as energy substra...
In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as an energy subs...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated ...
In the Peripheral nervous system (PNS), akin to the central, glial cells, Schwann cells and astrocyt...
Astrocytes of the central nervous system (CNS) provide glycogen derived lactate to axons when energy...
The ability of sciatic nerve A fibres to conduct action potentials relies on an adequate supply of e...
Central white matter and peripheral nerves function by conducting action potentials, which rely on t...
The stimulus evoked compound action potential (CAP), recorded using suction electrodes, provides an ...
International audienceWhile lactate shuttle theory states that glial cells metabolize glucose into l...
It is hypothesized that L-lactate derived from astrocyte glycogen sustains axon excitability in mous...
The role of glycogen in the central nervous system is intimately linked with the glycolytic pathway....
We asked whether, in a steady state, neurons and glial cells both take up glucose sufficient for the...
C. Vega in the Neurobiologie des processus adaptatifs laboratory from 2002International audienceWe a...
In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as energy substra...
In the optic nerve, oligodendrocytes maintain axonal function by supplying lactate as an energy subs...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term a...
In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated ...