Studi Karakteristik Farmasetis Mikrokristalin Selulosa dari Jerami Padi Varietas Lokal Bali

THE PHARMACEUTICAL CHARACTERISTICS STUDY OF MICROCRYSTALLINE CELLULOSE FROMRICE STRAWOF BALI'S LOCAL VARIETIES. Bali is famous for its agricultural system in Indonesia. Rice became the major agricultural commodities in Bali with its local varieties, Mansur. However, utilization of waste product not optimal. Cellulose that contained in rice straw is very high. It is potential to use rice straw for raw material of microcrystalline cellulose (MCC). Therefore, in this study, it needs to investigated the pharmaceutical characteristics of MCC from Mansur's rice straw to improve the utilization of rice waste product as an excipient in pharmaceutical formulation. There are two stage for produce MCC., namely delignification process and acid hydrolysis process. In first stage, it use NaOH solution at various concentrations (5%,7,5%, 10%, 12,5%and 15%) for 24 hours.Acid hydrolysis process carried out by usingHCl 2.5 N.MCC in various concentrations of NaOH then determined their pharmaceutical characteristics which are cellulose content, organoleptic, humidity, water solubility, pH, bulk density, tapped density, Carr's Index and Scanning Electron Microscope (SEM). In this study, MCC have been produced fromMansur's rice straw(MCCMS). In delignification process, the variation of NaOH concentration causes a differences cellulose content. The pharmaceutical characteristics, MCCMS-7.5% has the highest content of cellulose with a quite good of Carr's Index