The Immortal Strand Hypothesis proposes that asymmetrically dividing stem cells cosegregate chromatids to retain ancestral DNA templates. Using both pulse-chase and label retention assays, we show that non-random partitioning of DNA occurs in germline stem cells (GSCs) in the Drosophila ovary as these divide asymmetrically to generate a new GSC and a differentiating cystoblast. This process is disrupted when GSCs are forced to differentiate through the overexpression of Bag of Marbles, a factor that impels the terminal differentiation of cystoblasts. When Decapentaplegic, a ligand which maintains the undifferentiated state of GSCs, is expressed ectopically the non-random partitioning of DNA is similarly disrupted. Our data suggest asymmetri...
Although considered to be exact copies of each other, sister chromatids can segregate ...
Many adult stem cells undergo asymmetric cell division (ACD) to produce both a self-renewing stem ce...
Summary: Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological...
The Immortal Strand Hypothesis proposes that asymmetrically dividing stem cells cosegregate chromati...
Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell and a dif...
Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell and a dif...
Germline stem cells divide asymmetrically, producing a self-renewing stem cell and a differentiating...
Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific di...
Adult stem cells are proposed to have acquired special features to prevent an accumulation of DNA-re...
The Role of DNA Replication in Establishing Asymmetric Epigenetic Inheritance in the Drosophila Male...
Stem cells have the unique ability to undergo asymmetric division in order to produce two geneticall...
Understanding how stem cell fate is initiated, maintained, and terminated is important, as improper ...
In most tissues, homeostasis is maintained by adult stem cells. These cells have the unique capacity...
A limited number of adult stem cells (SCs) maintain the homoestasis of different tissues through the...
Germline stem cells divide asymmetrically to produce one new daughter stem cell and one daughter cel...
Although considered to be exact copies of each other, sister chromatids can segregate ...
Many adult stem cells undergo asymmetric cell division (ACD) to produce both a self-renewing stem ce...
Summary: Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological...
The Immortal Strand Hypothesis proposes that asymmetrically dividing stem cells cosegregate chromati...
Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell and a dif...
Many stem cells utilize asymmetric cell division (ACD) to produce a self-renewed stem cell and a dif...
Germline stem cells divide asymmetrically, producing a self-renewing stem cell and a differentiating...
Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific di...
Adult stem cells are proposed to have acquired special features to prevent an accumulation of DNA-re...
The Role of DNA Replication in Establishing Asymmetric Epigenetic Inheritance in the Drosophila Male...
Stem cells have the unique ability to undergo asymmetric division in order to produce two geneticall...
Understanding how stem cell fate is initiated, maintained, and terminated is important, as improper ...
In most tissues, homeostasis is maintained by adult stem cells. These cells have the unique capacity...
A limited number of adult stem cells (SCs) maintain the homoestasis of different tissues through the...
Germline stem cells divide asymmetrically to produce one new daughter stem cell and one daughter cel...
Although considered to be exact copies of each other, sister chromatids can segregate ...
Many adult stem cells undergo asymmetric cell division (ACD) to produce both a self-renewing stem ce...
Summary: Adult and embryonic stem cells exhibit fluctuating gene expression; however, the biological...