Dave Singh, Arjun Ravi, Thomas Southworth Division of Infection, Immunity and Respiratory Medicine, The Medicines Evaluation Unit, Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, The University of Manchester, Manchester, UK Abstract: Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) binds to prostaglandin D2. CRTH2 is expressed on various cell types including eosinophils, mast cells, and basophils. CRTH2 and prostaglandin D2 are involved in allergic inflammation and eosinophil activation. Orally administered CRTH2 antagonists are in clinical development for the treatment of asthma. The biology and clinical trial data indicate that CRTH2 antagonists should be targeted...
Prostaglandin D2 (PGD2) is a pleiotropic mediator, significantly involved in the pathogenesis of typ...
The prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. The effic...
AbstractThe prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. T...
ABSTRACT: CRTH2 (chemoattractant receptor expressed on T-helper (Th) type 2 cells) is a G-protein-co...
BACKGROUND: CRTH2 is a G-protein-coupled receptor that mediates the activation of Th2 lymphocytes, e...
INTRODUCTION: Asthma is a chronic inflammatory disease characterized by bronchial hyper-reactivity. ...
Piotr Kuna,1 Leif Bjermer,2 Göran Tornling3,4 1Department of Internal Medicine, Asthma and All...
Background: Chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cell (CR...
Background: Mast cell-derived prostaglandin D-2 (PGD(2)), may contribute to eosinophilic inflammatio...
CRTh2 (DP2) is implicated in the pathogenesis of asthma; however, currently there is a lack of data ...
CRTH2 is a G protein-coupled receptor expressed by Th2 lymphocytes and eosinophils that mediates pro...
Prostaglandin D2 (PGD2) is a major cyclooxygenase mediator that is synthesized by activated human ma...
Eric D Bateman,1 Christopher O’Brien,2 Paul Rugman,2 Sally Luke,2 Stefan Ivanov,2 Mohib Uddin2...
Introduction: Asthma is a major disease burden worldwide. Treatment with steroids and long acting β-...
Hits from an in silico derived focused library for CRTH2 were transformed into highly selective anta...
Prostaglandin D2 (PGD2) is a pleiotropic mediator, significantly involved in the pathogenesis of typ...
The prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. The effic...
AbstractThe prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. T...
ABSTRACT: CRTH2 (chemoattractant receptor expressed on T-helper (Th) type 2 cells) is a G-protein-co...
BACKGROUND: CRTH2 is a G-protein-coupled receptor that mediates the activation of Th2 lymphocytes, e...
INTRODUCTION: Asthma is a chronic inflammatory disease characterized by bronchial hyper-reactivity. ...
Piotr Kuna,1 Leif Bjermer,2 Göran Tornling3,4 1Department of Internal Medicine, Asthma and All...
Background: Chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cell (CR...
Background: Mast cell-derived prostaglandin D-2 (PGD(2)), may contribute to eosinophilic inflammatio...
CRTh2 (DP2) is implicated in the pathogenesis of asthma; however, currently there is a lack of data ...
CRTH2 is a G protein-coupled receptor expressed by Th2 lymphocytes and eosinophils that mediates pro...
Prostaglandin D2 (PGD2) is a major cyclooxygenase mediator that is synthesized by activated human ma...
Eric D Bateman,1 Christopher O’Brien,2 Paul Rugman,2 Sally Luke,2 Stefan Ivanov,2 Mohib Uddin2...
Introduction: Asthma is a major disease burden worldwide. Treatment with steroids and long acting β-...
Hits from an in silico derived focused library for CRTH2 were transformed into highly selective anta...
Prostaglandin D2 (PGD2) is a pleiotropic mediator, significantly involved in the pathogenesis of typ...
The prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. The effic...
AbstractThe prostaglandin D2 (PGD2) receptor, CRTH2, plays a role in allergic airway inflammation. T...