Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

Betul Tugcu
Senay Asik Nacaroglu
Asuman Gedikbasi
Mehmet Uhri
Nur Acar
Hakan Ozdemir

Open link

Publication date

November 2017

DOI

10.18240/ijo.2017.11.05

Publisher

Press of International Journal of Ophthalmology (IJO Press)

Journal

International Journal of Ophthalmology

Abstract

AIM: To investigate the effect of pomegranate juice (PJ) intake on overall oxidation status in retinas of diabetic rats. METHODS: Twenty-seven rats were divided into four groups as control (CO), diabetic (DM), control treated with PJ (CO-PJ), and diabetic treated with PJ (DM-PJ).The retina tissues were used to determine 8-hydroxy-2’-deoxyguanosine (8OHdG), malondialdehyde (MDA), reduced glutathione (GSH) levels, and the enzyme activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). RESULTS: The levels of 8OHdG and MDA were significantly increased in the retina of DM group compared to CO group (P=0.001, P<0.001 respectively). Both 8OHdG and MDA levels were decreased in PJ-DM group compared to DM group (P=0.004, P<0.00...