Programming of the hypothalamo-pituitary-adrenal (HPA) axis during prenatal and early postnatal life may explain, in part, the association between low birth weight (BW) and the increased incidence of cardiovascular and metabolic disease in later life. This study examined the effect of natural variations in BW on HPA axis function in juvenile and adult pigs. Low (< 1.47 kg) and high (> 1.53 kg) BW pure-bred Large White piglets from 15 litters were studied at 3 (n = 47) and 12 (n = 17) months of age. At each age, HPA axis function was tested by hypoglycaemic challenge (I.V. insulin; 0.5 IU (kg body weight)-1) and ACTH challenge (I.V. Synacthen, 2 µg (kg body weight)-1). At 3 months of age, adrenal size, the ratio of adrenal cortical to ...
The early-life environment affects risk of later metabolic disease, including glucose intolerance, i...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...
In man, epidemiological studies have shown that low birth weight (BW) is associated with an increase...
Low birth weight is associated with altered adipose tissue deposition and regulation of leptin produ...
Low birth weight is associated with an increased risk of impaired glucose tolerance and type 2 diabe...
Aims/hypothesis We have previously demonstrated poor glucose tolerance in adult pigs of naturally oc...
Aims/hypothesis: the aim of this study was to examine the effect of birth weight on glucose toleranc...
Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pit...
Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pit...
BACKGROUND: The sustainability of farming and animal welfare requires the reconsideration of curren...
Abstract In utero heat stress alters postnatal physiological and behavioral stress responses in pigs...
Prenatal stress is known to affect several offspring characteristics, but its effects depend among o...
Abstract Background The sustainability of farming and animal welfare requires the reconsideration of...
The perinatal environment is a powerful determinant of risk for developing disease in later life. He...
The early-life environment affects risk of later metabolic disease, including glucose intolerance, i...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...
In man, epidemiological studies have shown that low birth weight (BW) is associated with an increase...
Low birth weight is associated with altered adipose tissue deposition and regulation of leptin produ...
Low birth weight is associated with an increased risk of impaired glucose tolerance and type 2 diabe...
Aims/hypothesis We have previously demonstrated poor glucose tolerance in adult pigs of naturally oc...
Aims/hypothesis: the aim of this study was to examine the effect of birth weight on glucose toleranc...
Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pit...
Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pit...
BACKGROUND: The sustainability of farming and animal welfare requires the reconsideration of curren...
Abstract In utero heat stress alters postnatal physiological and behavioral stress responses in pigs...
Prenatal stress is known to affect several offspring characteristics, but its effects depend among o...
Abstract Background The sustainability of farming and animal welfare requires the reconsideration of...
The perinatal environment is a powerful determinant of risk for developing disease in later life. He...
The early-life environment affects risk of later metabolic disease, including glucose intolerance, i...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objec...