NEUROENDOCRINE CARCINOMA OF THE UTERUS

Neuroendocrine carcinoma of the cervix and endometrium are very rare and aggressive tumours. The present case study is of a 52 year old female who was a known case of hypertension and diabetes mellitus and presented to Sir Ganga Ram Hospital with postmenopausal bleeding per vaginum with moderately differentiated adenocarcinoma reported on endometrial biopsy done outside. Patient underwent total Laparoscopic Radical Hysterectomy with staging and bilateral pelvic lymphadenectomy. Her final FIGO staging was stage Ib.­­ Histopathology confirmed poorly differentiated endometroid carcinoma of fundus of uterus involving up to 2/3rd of myometrium with immunohistochemistry positive for cytokeratin, synaptophysin and 10-15% of tumour cells positive for Ki67, thus confirming the diagnosis of neuroendocrine carcinoma. So, it was concluded that the diagnosis of neuroendocrine carcinoma has to be kept in mind while treating patients with bleeding per vaginum especially in perimenopausal and postmenopausal group. A multispeciality approach is a key to the management on such a group of patients, to yield the best of results