A STUDY OF OUTCOME OF INTRA-OPERATIVE TOPICAL APPLICATION OF 5- FLUOROURACIL (5-FU) IN TRABECULECTOMY

Aim: A study of long term efficacy and ocular toxicity of intra-operative topical application of 5-FU in trabeculectomy. Material & Methods: The study includes retrospective analysis of 43 eyes of 22 patients who underwent trabeculectomy with intra-operative application of 5- FU. Results: With minimum 6 months follow up 34 eyes (79 %) got good IOP control without medication. 7 eyes (16.30 %) got good IOP control with 1 topical drug. 1 eye (2.33 %) got intractable neo vascular glaucoma and 1 eye (2.33 %) got malignant glaucoma. There were no corneal complications seen. Only 3 eyes (6.97 %) got persistent hypotony in 6 months follow up and 1 eye (2.33 %) got bleb related endophthalmitis after 2 years following trauma. Conclusion: Our study shows that intra-operative use of 5-FU is safe and effective alternative to mitomycin c