Probiotic and fermented milk: prophylactic and therapeutic effects in childhood diarrhoea

Iznijeli smo novije znanstvene spoznaje o profilaktičkim agensima i fermentiranom mlijeku i njihovu ulogu u profilaksi i liječenju proljeva u djece. Bolja podnošljivost laktoze u mlijeku koje sadrže žive bakterijske kulture povezuje se sa smanjenim sadržajem laktoze i djelovanjem bakterijskih betagalaktozidaza u crijevnom lumenu. Nizak pH fermentiranog mlijeka mote spriječiti rast ili čak uništiti patogene u crijevu. Buduća istraživanja trebaju voditi računa o dozi, učincima specifičnih vrsta bifidobakterija i laktobacila na imuni odgovor i stvaranje inhibitornih supstancija protiv patogena.We have presented recent scientific information about probiotics agents and fermentative milk, and their protective and therapeutic effect in childhood diarrhoea. The improved tolerance to lactose when consumed as cultured milk containing live bacterial cultures, is as least related to the reduced lactose level and microbial beta-galactosidase acting in the small bowel Low pH due to lactic acid in fermented milk prevent growth and can even kill intestinal patogens. Future studies should focus in specif strain of bifidobacteria and lactobacilli with attention to dose, effects of these agents on immune response by the host, and production of inhibitory factors against pathogens