Does the use of vitamin C affect the development of vascular complicatins in patients with diabetes?

Vitamin C predstavlja esencijalni mikronutrijent s poznatim antioksidativnim efektom. Oksidativni stres je osnovni patofiziološki mehanizam oštećenja endotela. Podaci o pojavnosti dijabetesa i primjeni vitamina C su kontroverzni, a u regulaciji glikemije mogu se očekivati povoljni učinci nakon uzimanja vitamina C. S obzirom na antioksidativna svojstva vitamina C, povoljan učinak uzimanja može se očekivati i kod dijabetičara sa zatajivanjem srčane funkcije, kao i kod pacijenata s ishemijskim moždanim udarom. Niska razina C vitamina u plazmi kod dijabetičara tipa 1 uzrokuje smetnje u repolarizaciji klijetki. Primjena vitamina C nema povoljan učinak na perifernu cirkulaciju donjih udova, a ima povoljan na cirkulaciju u gornjim ekstremitetima. Vitamin C vjerojatno ima i povoljan učinak na usporavanje razvoja dijabetičke nefropatije i neuropatije, dok je učinak na razvoj retinopatije dvojben. Za razliku od dijastoličkog, sistolički arterijski tlak može biti dodatno snižen primjenom vitamina C. Obzirom na kontroverzne podatke za sada se ne preporuča rutinsko uzimanje vitamina C u preparatima koji su dodatak prehrani sa svrhom smanjenja kardiovaskularnih rizika. I dalje vrijedi preporuka o što većem uzimanju voća i povrća u svakodnevnoj prehrani.Vitamin C is an essential micronutrient with well-known antioxidant effect. Oxidative stress is the underlying pathological state of endothelial damage. Data on the incidence of diabetes and the use of vitamin C are controversial, while some beneficial effects can be expected in the regulation of blood glucose levels after taking vitamin C. Considering the antioxidant properties of vitamin C, a beneficial effect of taking vitamin C can be also expected in diabetic patients with heart failure and in patients with ischemic stroke. A low level of vitamin C in plasma in type 1 diabetic patients causes ventricular repolarization disturbances. The use of vitamin C does not have a beneficial effect on the peripheral circulation of the lower limbs, but it has a beneficial effect on the circulation in the upper limbs. Vitamin C probably has a beneficial effect on slowing down the development of diabetic nephropathy and neuropathy, while the impact on the development of retinopathy is uncertain. Unlike the diastolic pressure, systolic blood pressure can be further decreased by administering vitamin C. Considering the controversial data, for the time being we still do not advise regular intake of vitamin C in products that are dietary supplements for the purpose of reducing cardiovascular risks. The advice on eating as greater amounts of fruit and vegetables as possible in a daily diet still applies