ショウカンサイボウガン ノ ニクガンケイ ブンルイ カラ ミタ シュヨウ トクセイ : サイボウ ゾウショクノウ ト Doubling Time ノ カンテン カラ

It is reported that gross classification of hepatocellular carcinoma (HCC) is associated with tumors’ malignant behavior.We studied the characteristics and differences between two types of gross classification of HCCs (i.e. Boundary type:single nodular HCC; Nonboundary type: single nodular with extranodular growth, confluent multinodular, and invasiveHCCs) by using MIB-1 labeling index (LI) and tumor volume doubling time (DT). The DT of 87 HCCs, less than 5 cm in diameter at the start of the observation period, was calculated based onultrasonographic images. The natural progression of the lesions were observed during 1 month or more.Regarding MIB-1 labeling index (LI) of the 87 lesions, we performed immunohistochemical staining (ABC method) withthe MIB-1 monoclonal antibody using paraffin-embedded sections obtained by liver resection. The incidence of micrometastasis in the resected sections and the postoperative recurrence ratio were clearly higher inthe nonboundary type (n=19) than in the boundary type (n=68). MIB-1 LI and DT were 12.1 +/- 1.3% (mean +/- SE) and274.8 +/- 36.2 days in the boundary type and 14.2 +/- 2.0% and 103.9 +/- 13.4 days in the nonboundary type. A significantdifference of DT was noticed between the 2 groups. These results showed that the nonboundary type HCCs included tumors with rapid growth more than those in theboundary type. Calculating DT would assist in distinguishing gross classification preinterventionally and in determiningsuitable therapy such as liver resection and ablation