Morfologija testisa i zalihe sperme u epididimisu štakora nakon prestanka davanja nigerijske sirove nafte Qua Iboe Brent

The reversibility of crude oil-induced male reproductive abnormalities was studied in fifi fty-six male Sprague-Dawley rats. Exposure to crude oil was achieved by oral administration of increasing doses (165mg/kg body mass, 330mg/kg body mass, and 660mg/kg body mass) of Nigerian Qua Iboe Brent crude oil to male rats every 48 hours for 4 weeks. Thereafter, the crude oil was withdrawn from some of the rats for a period of 8 weeks. The results showed signififi cant reduction in the cauda epididymal sperm reserves of the rats that received the crude oil (P<0.05) and the rats from which the crude oil was withdrawn (P<0.05), relative to the control group. The testes of the rats that received crude oil showed reduced spermatogenic activity in the seminiferous tubules, as well as hyperaemia and oedema of the interstices. The testes of the rats from which crude oil was withdrawn showed evidence of recovery and the restoration of active spermatogenesis in the seminiferous tubules. The indication is that the withdrawal of Nigerian Qua Iboe Brent crude oil from male rats over a period of 8 weeks reversed the testicular pathology, but not the cauda epididymal oligospermia associated with this environmental pollutant.Reverzibilnost reprodukcijskih poremećaja uzrokovanih sirovom naftom istraživana je na 56 štakora Sprague-Dawley. Peroralno su štakorima bile davane sve veće doze (165 mg/kg tjelesne mase, 330 mg/kg tjelesne mase i 660 mg/kg tjelesne mase) nigerijske Qua Iboe Brent sirove nafte svakih 48 sati tijekom četiri tjedna. Nakon toga neki od štakora više nisu dobivali sirovu naftu u razdoblju od osam tjedana. Rezultati su pokazali značajno smanjenje rezervi sperme u epididimisu štakora koji su dobivali sirovu naftu (P<0,05) i u štakora kojima se prestalo davati sirovu naftu (P