J Diabetes

BackgroundThere is limited information from population-based investigations of the associations between sleep duration and sleep disorders and parameters of glucose homeostasis. The objective of the present study was to examine cross-sectional associations between sleep duration and sleep disordered breathing with concentrations of insulin, fasting and 2-h glucose, and HbA1c.MethodsData from 11 815 adults aged \ue2\u2030\ua520 years without diagnosed diabetes (5002 with an oral glucose tolerance test) from the National Health and Nutrition Examination Survey 2005\ue2\u20ac\u201c2010 were used. Information about sleep duration (2005\ue2\u20ac\u201c2010) and sleep apnea and sleep-disordered breathing (2005\ue2\u20ac\u201c2008) was obtained via questionnaire.ResultsAn estimated 36.0% of participants reported sleeping \ue2\u2030\ua46 h/night, 62.0% reported sleeping 7\ue2\u20ac\u201c9 h/night, and 2.0% reported sleeping \ue2\u2030\ua510 h/night. In 2005\ue2\u20ac\u201c2008, 33.0% reported snoring \ue2\u2030\ua55 nights per week, 5.9% reported they snorted, gasped, or stopped breathing \ue2\u2030\ua55 nights/week, and 4.2% reported sleep apnea. Sleep duration was significantly associated with fasting concentrations of insulin and concentrations of HbA1c only in models that did not adjust for body mass index (BMI). Concentrations of fasting and 2-h glucose were significantly associated with sleep duration in models that adjusted only for age. Snoring frequency was positively associated with concentrations of insulin and HbA1c. Frequency of snorting or stopping breathing and sleep apnea status were associated with concentrations of insulin and of HbA1c only when BMI was not accounted for.ConclusionIn a representative sample of US adults, concentrations of insulin and HbA1c were significantly associated with short sleep duration, possibly mediated by BMI.IPO9/Intramural CDC HHS/United States2015-09-02T00:00:00Z24164804PMC455769