NIOSH skin notation profiles : epichlorohydrin

"This Skin Notation Profile presents (1) brief summary of technical data associated with skin contact with epichlorohydrin and (2) the rationale behind the hazard-specific skin notation (SK) assignment for epichlorohydrin. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to epichlorohydrin. A literature search was conducted through July 2010 to identify information on epichlorohydrin, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to epichlorohydrin. Epichlorohydrin is potentially capable of causing numerous adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for epichlorohydrin: SK: SYS-DIR (COR)-SEN. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for epichlorohydrin." - NIOSHTIC-2Foreword -- Abbreviations -- Glossary -- Acknowledgments -- 1. Introduction -- 1.1. General Substance Information -- 1.2. Purpose -- 1.3. Overview of SK Assignment for Epichlorohydrin -- 2. Systemic Toxicity from Skin Exposure (SK: SYS) -- 3. Direct Effects on Skin (SK: DIR) -- 4 Immune-mediated Responses (SK: SEN) -- 5. Summary -- References -- Appendix: Calculation of the SI Ratio for Epichlorohydrin"This document was developed by the Education and Information Division, Paul Schulte, Ph.D., Director. G. Scott Dotson, Ph.D. was the project officer for this document. Other NIOSH personnel, in particular Gregory A. Day, Ph.D., Charles L. Geraci, Ph.D., Thomas J. Lentz, Ph.D., Richard Niemeier, Ph.D., and Anna Shvedova, Ph.D., contributed to its development by providing technical reviews and comments. The basis for this document was a report contracted by NIOSH and prepared by Bernard Gadagbui, Ph.D., and Andrew Maier, Ph.D. (Toxicology Excellence for Risk Assessment [TERA])." -- p. ix"April 2011."Includes bibliographical references (p. 6-8).Also available via the World Wide Web as Acrobat .pdf file (PDF - 687.17 KB, 24 p.)